منابع مشابه
A simpler twist of fate.
Until the day it dies, a cell that has become a skin cell remains a skin cell — or so scientists used to think. Over the past decade, it has become clear that cellular identity is not written in stone but can be rewritten by activating specific genetic programs. Today, the field of regenerative medicine faces a question: should this rewriting take the conventional route, in which mature cells a...
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In a recent issue of Nature, Qian et al (2012) show that by injecting adult mouse hearts with a few transcription factors on a retroviral vector, they can switch cardiac fibroblasts—the workhorse supporting cells of the heart—into cardiomyocytes, the beating muscle cells driving the contractile forces that pump blood. When injected into the hearts of mice with induced myocardial infarctions, th...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2017
ISSN: 0925-4773
DOI: 10.1016/j.mod.2017.04.561